This training course covers the fundamentals of container closure integrity testing (CCIT), with a particular focus on the integrated use of positive controls (simulated leaks) during probabilistic and deterministic testing.
CCIT regulations and guidelines in the US, EU, Asia
Overview of probabilistic vs deterministic CCIT methods
Overview of the different types of positive controls (micropipette, wire, capillary, orifice plate, laser drilling), pros and cons, recent technological advancements
Case study of how positive controls can be used in an integrated fashion